PFOA
Pentadecafluorooctanoic acid · CAS 335-67-1
What you need to know
PFOA is a man-made chemical that was used for decades to make non-stick coatings and water-resistant materials. It is one of the most studied “forever chemicals” — it does not break down in the environment or in your body.
Most people are exposed through drinking water, food packaging, and older non-stick cookware. Once in your blood, PFOA stays there for years.
Research links PFOA to kidney cancer, thyroid disease, high cholesterol, and weaker vaccine responses in children. Major manufacturers phased it out of US production by 2013, but it is still found in older products and in the environment.
Technical detail
Molecular formula C8HF15O2
Carbon chain length C8 (long-chain perfluoroalkyl carboxylic acid)
Human serum half-life ~2.7–3.8 years
Environmental persistence Extremely high — carbon-fluorine bonds resist degradation
Stockholm Convention Listed as a persistent organic pollutant (Annex A, 2019)
IARC classification Group 1 — carcinogenic to humans (2023)
Health effects
Increased risk of kidney cancer
Established
Increased risk of testicular cancer
Established
Reduced vaccine antibody response
Higher risk in childrenEstablished
Elevated cholesterol and liver enzymes
Established
Thyroid hormone disruption and disease
Probable
Pregnancy-induced hypertension, pre-eclampsia
Higher risk in pregnancyProbable
Reduced birth weight
Higher risk in childrenProbable
Endocrine system disruption
Suspected